The aim of this workshop is to bring together multidisciplinary experts and users to identify the new challenges in Human-CPS-Interactions. One conference tutorial will be dedicated to state of the art on the different kinds of modeling, and another tutorial on how to integrate sociology and psychology aspects in CPS. The four conference sessions will focus on human-machine symbiosis, humans as operators of complex systems, humans as agents in multi-agent systems and the human as a part in controlled systems.